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People Exposed to Covid May Need to Take as Many as Three At-Home Tests, F.D.A. Says

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People Exposed to Covid May Need to Take as Many as Three At-Home Tests, F.D.A. Says
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The U.S. Food and Drug Administration issued a new recommendation on Thursday that asymptomatic people who are using at-home Covid-19 antigen tests take at least three tests, each spaced 48 hours apart, to reduce the odds of missing an infection.

People who have Covid-19 symptoms should take at least two tests, 48 hours apart, according to the agency.

The new guidelines come as the highly transmissible BA.5 subvariant of Omicron continues to spread, and after the Centers for Disease Control and Prevention eased its recommendation for routine surveillance testing in most circumstances.

Many people have reported that at-home tests failed to detect their infections, but studies have generally shown that rapid antigen tests are as good at detecting Omicron as they were at detecting Delta, the previous variant of concern.

Experts have long noted that rapid antigen tests, which are less sensitive than P.C.R. tests, are designed to be use serially, and that they are most likely to detect the coronavirus when people take them repeatedly over the course of several days.

But the new recommendations emphasize the need for “additional testing over a longer period of time,” the agency said.

“The F.D.A.’s new recommendations for at-home Covid-19 antigen tests underscore the importance of repeat testing after a negative test result in order to increase the chances of detecting an infection,” Dr. Jeff Shuren, the director of the agency’s Center for Devices and Radiological Health, said in a statement.

The new guidance is based on the results of a new national study, which has not yet been published in a scientific journal. The study, led by researchers at the University of Massachusetts Chan Medical School, focused on 154 people who tested positive for the virus using P.C.R. tests between October 2021 and February of this year.

It found that among symptomatic people, two tests taken 48 hours apart detected 93 percent of infections. But the same testing pattern detected just 63 percent of infections in asymptomatic people.

When people without symptoms took three tests, each two days apart, the tests caught 79 percent of infections.

The results suggest that “serial testing with antigen tests remains a useful way to detect infection,” Nathaniel Hafer, a molecular biologist at UMass Chan Medical School and an author of the study, said in a statement.

People who are worried that they may be infected even after receiving two or three negative results on at-home antigen tests can continue to test themselves, seek out a more sensitive P.C.R. test or consult with a doctor, the F.D.A. said.

Those who test positive using at-home tests, the agency said, should assume that they are infected and follow the guidelines set forth by the C.D.C.

The C.D.C. updated its Covid-19 guidance on Thursday but did not change its recommendation that people who test positive for the coronavirus isolate at home for at least five days.

People do not need to use the same brand of test each time, the F.D.A. said.

“If you plan to use at-home COVID-19 antigen tests, have several tests on hand so you can test more than once,” the agency said.

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